Validation of the <scp>ABC</scp> Method for Gastric Cancer Risk Stratification Across <i>Helicobacter pylori</i> Infections With Diverse CagA Status and Subtypes in Brazil
These findings demonstrate the clinical relevance of CagA diversity for gastric cancer risk assessment. Although limited to an endoscopy-referred cohort, the ABC method reliably identified low-risk individuals (Group A) and may help reduce unnecessary endoscopies in screening programs, regardless of CagA status and subtypes. Broader, population-based studies are needed to validate its generalizability and optimize its implementation.
Authors
- Asuka Furukawa
- Heinrich Seidler
- Leonard Da Silva (ORCID: https://orcid.org/0000-0001-6751-6819)
- Tecio de Araujo Couto
- Daisuke Kobayashi (ORCID: https://orcid.org/0000-0001-9755-6168)
- Yoshifumi Mizuguchi (ORCID: https://orcid.org/0000-0002-4943-5676)
- Kenichi Ohashi
- Keisuke Uchida
- José Guilherme Nogueira da Silva
- Jorge Alberto Capra Biasuz
- Kurara Yamamoto (ORCID: https://orcid.org/0000-0002-5272-6458)
- R. B. Villaça
- Simone Perez Pilli
- Minako Takagi
- Renato Hassegawa
- Kouhei Yamamoto (ORCID: https://orcid.org/0000-0003-3883-4353)
- Ana Luiza Werneck–Silva (ORCID: https://orcid.org/0000-0002-2505-8394)
- Keiko Miura (ORCID: https://orcid.org/0000-0001-9238-6067)
- Junko Minami
- Eduardo Koji Marchi Ogawa
- Ricardo Ambrósio Fock (ORCID: https://orcid.org/0000-0002-7964-5973)
- Yoshinobu Eishi (ORCID: https://orcid.org/0000-0002-0521-1670)
- Masaki Sekine
- C. Ogura
- Edmar Tafner
- Aloísio Felipe-Silva
- Luís Masuo Maruta
Institutions
- Tokyo Medical and Dental University (JP)
- Universidade de São Paulo (BR)
- Hospital Santa Paula (BR)
- Instituto Brasiliense de Otorrinolaringologia (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
- Tokyo Medical and Dental University Hospital (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1002/cam4.71016
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Tokyo Medical and Dental University