ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells
In this study, we revealed and characterized a novel EBV transcript ebv-sisRNA-3 widely expressed in latently infected cells. The unique ebv-sisRNA-3-binding R-loop and G-quadruplex structures near lytic replication origin may play a significant role in EBV lytic replication.
Authors
- Raymond Wai Ming Lung (ORCID: https://orcid.org/0000-0002-0813-7429)
- Chun Kit Kwok (ORCID: https://orcid.org/0000-0001-9175-8543)
- Polly H. M. Leung (ORCID: https://orcid.org/0000-0003-2406-4773)
- Shin Yee Hui (ORCID: https://orcid.org/0009-0003-2934-9820)
- Danyang Ji (ORCID: https://orcid.org/0000-0003-1721-9482)
- Chi Man Tsang (ORCID: https://orcid.org/0000-0001-6817-4590)
- Kevin Y. Yip (ORCID: https://orcid.org/0000-0001-5516-9944)
- M. Liu
- Kwok Wai Lo (ORCID: https://orcid.org/0000-0002-3488-6124)
- Ee Ling Kong
- Melissa Sue Ann Chan
- Yuk Yu Chan
- Bo Wang (ORCID: https://orcid.org/0009-0000-4767-4713)
- Yi Shuai
- Xin Wang (ORCID: https://orcid.org/0000-0002-4715-4360)
- Qian Wu (ORCID: https://orcid.org/0000-0003-3345-4247)
- Man Wu (ORCID: https://orcid.org/0009-0005-5638-0131)
- Guang Zhu (ORCID: https://orcid.org/0000-0003-3802-3446)
- Grace Tin Yun Chung
Institutions
- City University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- Discovery Institute (US)
- Soochow University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Prince of Wales Hospital (CN)
- Institute for Advanced Study (DE)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1186/s13578-025-01437-3
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- City University of Hong Kong
- State Key Laboratory in Marine Pollution
- Croucher Foundation
- National Natural Science Foundation of China
- University Grants Committee
- Research Grants Council, University Grants Committee
- Chinese University of Hong Kong
- Innovation and Technology Commission - Hong Kong
- Innovation and Technology Fund
- Health and Medical Research Fund