Sex-based differences in survival after liver transplantation for colorectal cancer liver metastases: A multivariable analysis
This multicentre retrospective study analysed survival outcomes in 82 patients undergoing liver transplantation for colorectal liver metastases across seven US and European centres. Several factors, including female sex, high carcinoembryonic antigen levels, right-sided colorectal cancer, larger tumours, KRAS mutation, pN2-positive CRC, number of nodules, and no prior liver therapy, were linked to poorer outcomes. The study questions current prognostic models and selection criteria, emphasizing the need for more accurate tools to guide decision-making in patients with colorectal liver metastases.
Authors
- Jacopo Lanari (ORCID: https://orcid.org/0000-0002-1569-7918)
- Morten Hagness (ORCID: https://orcid.org/0000-0002-7979-0062)
- Umberto Cillo (ORCID: https://orcid.org/0000-0002-2310-0245)
- Mohammad Alì Mansournia (ORCID: https://orcid.org/0000-0003-3343-2718)
- Matteo Cescon (ORCID: https://orcid.org/0000-0003-1715-3794)
- Federico Aucejo (ORCID: https://orcid.org/0000-0001-7841-229X)
- Ilaria Billato (ORCID: https://orcid.org/0000-0002-3335-3254)
- Roberto Hernandez‐Alejandro (ORCID: https://orcid.org/0000-0002-2312-3498)
- Svein Dueland (ORCID: https://orcid.org/0000-0002-6125-6689)
- Koji Tomiyama (ORCID: https://orcid.org/0000-0002-4317-5455)
- Bassam Estfan (ORCID: https://orcid.org/0000-0002-0651-9749)
- Samuele Iesari
- Vincenzo Mazzaferro (ORCID: https://orcid.org/0000-0002-4013-8085)
- Matteo Serenari (ORCID: https://orcid.org/0000-0003-1471-8585)
- Carlo Sposito (ORCID: https://orcid.org/0000-0002-2276-2669)
- Pål‐Dag Line (ORCID: https://orcid.org/0000-0002-5884-9336)
- Laurent Coubeau (ORCID: https://orcid.org/0000-0002-3968-5591)
- Alessandro Vitale (ORCID: https://orcid.org/0000-0002-4548-8308)
- Alessandro Rovetta (ORCID: https://orcid.org/0000-0002-4634-279X)
Institutions
- Oslo University Hospital (NO)
- Cliniques Universitaires Saint-Luc (BE)
- Cleveland Clinic (US)
- Statistics Korea (KR)
- University of Padua (IT)
- University of Oslo (NO)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Rochester Medical Center (US)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Tehran University of Medical Sciences (IR)
- UCLouvain (BE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101505
- Citations
- 4
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.29