Adverse event profiles of four monomethyl auristatin E-conjugated antibody drug conjugates: a disproportionality analysis based on the US FDA adverse event reporting system (FAERS) database
FAERS analysis revealed overlapping safety signals in MMAE-conjugated ADCs. Although further research is necessary to clarify the causal relationships, our findings provide a basis for understanding the characteristics of possible AEs in MMAE-ADCs, aiding clinical decision-making for patient safety management.
Authors
- Takeshi Hirota (ORCID: https://orcid.org/0000-0002-4846-3421)
- Ichiro Ieiri (ORCID: https://orcid.org/0000-0002-3543-2562)
- Mayako Uchida (ORCID: https://orcid.org/0000-0003-0507-7309)
- Yuko Doi
Institutions
- Kyushu University (JP)
- Kyushu University Hospital (JP)
- MSD K.K. (Japan) (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Expert Opinion on Drug Safety
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1080/14740338.2025.2526790
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00