A 20-month longitudinal study to evaluate humoral and cellular immunity after COVID-19 vaccines
High antibody levels were maintained for up to six months following both homologous and heterologous vaccination. However, cellular immunity declined more markedly in the Sinovac-CoronaVac + Pfizer group, resulting in a higher proportion of non-responders. These findings underscore the importance of tailored booster strategies to sustain protective immunity against COVID-19.
Authors
- Bárbara Batista Salgado (ORCID: https://orcid.org/0000-0002-5318-1680)
- Leandro Mendonça do Nascimento (ORCID: https://orcid.org/0000-0002-6917-4274)
- Lisvane Paes‐Vieira (ORCID: https://orcid.org/0000-0001-8589-5939)
- Paulo Afonso Nogueira (ORCID: https://orcid.org/0000-0001-9677-7225)
- Pritesh Lalwani (ORCID: https://orcid.org/0000-0003-2996-0446)
- Aguyda Rayany Cavalcante Barbosa (ORCID: https://orcid.org/0000-0002-3644-9147)
- Jaila Dias Borges Lalwani (ORCID: https://orcid.org/0000-0002-8310-4264)
- Wlademir Braga Salgado Sobrinho
- Vanessa Araújo Passos
Institutions
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- Memórias do Instituto Oswaldo Cruz
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/0074-02760240193
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior