Iodide Salt-Catalyzed Oxidative Coupling of Benzofuran-3(2<i>H</i>)-ones with Acids and Amines Using Air as the Oxidant
A novel catalytic protocol enables efficient, environmentally benign oxidative coupling of benzofuran-3(2<i>H</i>)-ones with acids and amines. Employing iodide salts as catalysts and ambient air as the sole oxidant, this method delivers straightforward access to 2-acyloxyaminobenzofuran-3(2<i>H</i>)-ones and α-ketoamides with a broad substrate scope, excellent functional group tolerance, and good yields. The approach further demonstrates utility in late-stage functionalization of complex pharmaceuticals, highlighting its synthetic potential.
Authors
- Keting Gui (ORCID: https://orcid.org/0000-0001-6396-5158)
- Xinxin Zheng (ORCID: https://orcid.org/0000-0001-5319-9461)
- Xiande Luo
- Qinqin Xia (ORCID: https://orcid.org/0000-0002-0150-0280)
- Yueyue Fan (ORCID: https://orcid.org/0000-0002-6615-2029)
- Yuepiao Cai (ORCID: https://orcid.org/0000-0003-3178-1615)
- Yuan Cai (ORCID: https://orcid.org/0000-0003-0026-4930)
- Kexin Zhou (ORCID: https://orcid.org/0009-0007-1300-873X)
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1021/acs.joc.5c00687
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province