Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss, providing insights in the potential role of sex hormones in bone loss accompanying weight loss in older adults with T2D who are at a higher risk of bone fractures.
Authors
- Karen Johnson (ORCID: https://orcid.org/0000-0002-3493-4077)
- Wendy L. Bennett (ORCID: https://orcid.org/0000-0001-9828-0706)
- Nityasree Srialluri (ORCID: https://orcid.org/0000-0003-4715-1861)
- Erin D. Michos (ORCID: https://orcid.org/0000-0002-5547-5084)
- Mark Woodward (ORCID: https://orcid.org/0000-0001-9800-5296)
- Jianqiao Ma (ORCID: https://orcid.org/0009-0009-5001-1422)
- Teresa Gisinger (ORCID: https://orcid.org/0000-0001-8819-4425)
- Dhananjay Vaidya (ORCID: https://orcid.org/0000-0002-7164-1601)
- Chigolum P. Oyeka (ORCID: https://orcid.org/0000-0003-4102-3172)
- Jiahuan Helen He
- lakshmi Spurthi Kodali
Institutions
- Johns Hopkins University (US)
- University of Tennessee Health Science Center (US)
- The George Institute for Global Health (GB)
- Johns Hopkins Medicine (US)
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
- Imperial College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1210/clinem/dgaf359
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00