PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and alleviates chondrocyte osteoarthritis mediated by exosomal ANXA1
PPARγ/ESCRT - FLSs exosomal ANXA1 - ERK axis provides a deeper theoretical basis for exercise therapy of OA and a new idea for the clinical transformation of nanoparticles into OA therapy.
Authors
- Shuangshuo Jia
- Jia‐Bao Liu (ORCID: https://orcid.org/0000-0002-9620-7692)
- Ziyuan Wang (ORCID: https://orcid.org/0000-0002-7095-8527)
- Lunhao Bai (ORCID: https://orcid.org/0000-0001-8727-6920)
- Yue Yang (ORCID: https://orcid.org/0009-0007-4685-0296)
Institutions
- Shenyang Medical College (CN)
- Sun Yat-sen University (CN)
- Central Hospital Affiliated to Shenyang Medical College (CN)
- Sun Yat-sen Memorial Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.jot.2025.06.008
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province