Impact of stereotactic radiosurgery timing relative to immune checkpoint blockade administration on brain metastasis disease and radionecrosis outcomes
Delivering SRS closer to ICB cycles was associated with improved icPFS, LC, and OS without affecting radionecrosis rates. This may present a therapeutic opportunity to improve BrM outcomes.
Authors
- Michelle Li
- Xavier Fitzgerald
- Claire Phillips (ORCID: https://orcid.org/0000-0001-7215-8729)
- Joseph Sia (ORCID: https://orcid.org/0000-0002-9056-0903)
- Nikki Plumridge
- Anthony Green (ORCID: https://orcid.org/0000-0002-5805-3004)
- Anika Mittal
- Andrew Wirth
- Lavinia Spain
- Neda Haghighi
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Peter MacCallum Cancer Centre (AU)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf130
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52