Exploring the link between personality dimensions and non-motor fluctuations in Parkinson's disease
BackgroundParkinson's disease (PD) patients on dopaminergic drugs may experience non-motor fluctuations (NMFs) which are often heterogeneous and respond variably to treatments.ObjectiveWe evaluated if personality was associated to NMFs and could modulate the NMFs responsiveness to dopaminergic medication and deep brain stimulation of the sub-thalamic nucleus (STN-DBS).MethodsFrom the PREDISTIM cohort, personality dimensions of 235 PD patients were assessed by the Temperament and Character Inventory (TCI) before STN-DBS (V0). NMFs were evaluated using the NMFs Severity Scale at V0 and one year after STN-DBS (V1). Linear regression models were performed between TCI dimensions and NMFs at V0; and logistic regression models were done between TCI dimensions and 1) groups of dopa-sensitive patients (responders to ON medication at V0) versus non-dopa-sensitive ones, and 2) responders versus non-responders to STN-DBS at V1. Odds ratios (OR) were also calculated.ResultsSignificant associations were found between two TCI personality dimensions ("Harm Avoidance" and "Self-Directedness") and severity of NMFs in OFF medication at V0: PD patients with higher Harm Avoidance and lower Self-Directedness scores having more NMFs. TCI personality dimensions were not associated with the dopa-sensitivity while Novelty Seeking was significantly associated with the STN-DBS-responder group for the psychiatric (OR = 1.09 [1.02-1.17]) and for the dysautonomic NMFs (OR = 1.11 [1.04-1.18]).ConclusionsCertain personality dimensions (Harm Avoidance and Self-Directedness) are associated with NMFs severity at baseline, and PD patients with high Novelty Seeking seem to be better candidates for NMFs improvement after STN-DBS.
Authors
- Caroline Moreau (ORCID: https://orcid.org/0000-0002-8637-6249)
- Mélissa Tir
- Tiphaine Rouaud (ORCID: https://orcid.org/0000-0003-2885-7906)
- Mathilde Boussac (ORCID: https://orcid.org/0000-0002-3532-6743)
- Ana Marquès (ORCID: https://orcid.org/0000-0003-2428-4899)
- Émeline Descamps (ORCID: https://orcid.org/0000-0002-0675-2989)
- Anne‐Sophie Rolland (ORCID: https://orcid.org/0000-0001-7888-9354)
- Bruno Giordana (ORCID: https://orcid.org/0000-0001-7293-6607)
- Élodie Hainque (ORCID: https://orcid.org/0000-0001-9049-6246)
- David Devos (ORCID: https://orcid.org/0000-0002-2417-799X)
- Lucie Hopes (ORCID: https://orcid.org/0009-0008-2982-0658)
- Florent Faggianelli (ORCID: https://orcid.org/0000-0003-1007-7522)
- Estelle Harroch
- Fabienne Ory‐Magne (ORCID: https://orcid.org/0000-0001-6179-4500)
- Tatiana Witjas
- Sophie Drapier
- Margherita Fabbri (ORCID: https://orcid.org/0000-0001-7250-592X)
- Béchir Jarraya (ORCID: https://orcid.org/0000-0003-0878-763X)
- Jean‐Philippe Azulay (ORCID: https://orcid.org/0000-0001-6624-3329)
- David Maltête (ORCID: https://orcid.org/0000-0002-5246-3379)
- Mathieu Anheim (ORCID: https://orcid.org/0000-0001-8121-0605)
- Christine Brefel‐Courbon (ORCID: https://orcid.org/0009-0002-7262-2338)
- Olivier Rascol
- Dominique Guehl (ORCID: https://orcid.org/0000-0003-0388-6727)
- Jean‐Philippe Brandel
- Chloé Laurencin
- Solène Ansquer
- Alexandre Eusébio (ORCID: https://orcid.org/0000-0003-4923-0248)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Institut Pascal (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Clermont Auvergne (FR)
- Aix-Marseille Université (FR)
- Université de Lille (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Institut des Maladies Neurodégénératives (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Clinical Investigation Center Plurithematic Tours (FR)
- Hôpital Pierre Wertheimer (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- CIC Rennes (FR)
- Sigma Clermont (FR)
- Fondation de Rothschild (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- CEA Paris-Saclay (FR)
- Institut de Neurosciences de la Timone (FR)
- Hôpital Pasteur (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Institut du Cerveau (FR)
- French Clinical Research Infrastructure Network (FR)
- Lille Neurosciences & Cognition (FR)
- Neuroendocrine, Endocrine and Germinal Differentiation Communication
- Université de Rouen Normandie (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1177/1877718x251354932
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AXA Research Fund
- Association France Parkinson
- Centre hospitalier régional universitaire de Lille
- Centre Hospitalier Universitaire de Clermont-Ferrand
- Centre Hospitalier Universitaire de Rennes
- Centre Hospitalier Universitaire de Poitiers