High Antitumor Effects and Reduced Side Effects of Doxorubicin Prodrug Active Only Under Hypoxic Conditions
The DOX prodrug developed by our group showed tumor-suppressive effects comparable to those of DOX while being able to suppress blood toxicity, cardiotoxicity, as well as liver and testicular dysfunction.
Authors
- Tomohiko Sakuda
- Nobuo Adachi (ORCID: https://orcid.org/0000-0002-5570-3729)
- Katsuhito Yoshioka (ORCID: https://orcid.org/0000-0002-7488-3139)
- Yukio Nagasaki (ORCID: https://orcid.org/0000-0001-7975-6510)
- Shigeru Miyaki (ORCID: https://orcid.org/0000-0002-1602-5777)
- Taisuke Furuta (ORCID: https://orcid.org/0000-0002-0566-2973)
- Yutaka Ikeda (ORCID: https://orcid.org/0000-0002-0926-1886)
- Akihiro Oda
Institutions
- Hiroshima University (JP)
- University of Tsukuba (JP)
- Hiroshima University Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.21873/anticanres.17658
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00