Effective Targeting of Glioma Stem Cells by BSJ-04-122, a Novel Covalent MKK4/7 Dual Inhibitor
BSJ-04-122 is a first-in-class covalent dual inhibitor of MKK4/7 that selectively targets GSCs by inhibiting JNK signaling, leading to cell death or loss of stem-like properties. These findings support a therapeutic strategy that combines BSJ-04-122 to eliminate GSCs with conventional therapies targeting non-stem glioblastoma cells, offering a rational and potentially effective approach for treating this aggressive brain tumor.
Authors
- Keita Togashi
- Yurika Nakagawa-Saito (ORCID: https://orcid.org/0000-0002-9904-8842)
- MASASHI OKADA
- Asuka Sugai
- Chifumi Kitanaka
- Yoshinori Ito (ORCID: https://orcid.org/0000-0001-7199-7088)
- Kazuki Nakamura (ORCID: https://orcid.org/0000-0002-6322-762X)
- Yukihiko Sonoda (ORCID: https://orcid.org/0000-0001-7651-1374)
- Yuta Mitobe (ORCID: https://orcid.org/0009-0004-6963-6004)
- Senri Takenouchi
- Shuhei Suzuki (ORCID: https://orcid.org/0000-0003-1975-0146)
Institutions
- Yamagata University (JP)
- Yamagata Prefectural Shinjo Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.21873/anticanres.17659
- Citations
- 1
- Primary Topic
- Synthesis of Tetrazole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.94