Evolution of tandem repeats in putative circumsporozoite protein to enhance its function: A recent and exclusive event in Plasmodium vivax in India
The recent and exclusive accumulation of repeats in the putative circumsporozoite protein within Indian <i>P. vivax</i> highlights its highly variable length polymorphism, making it a potential marker for estimating diversity and infection complexity. Episodic diversifying selection in the <i>Pv</i>puCSP repeat region, supported by statistically significant <i>p</i>-values and likelihood ratios, contributes to amino acid diversity at various phylogenetic levels. Our previous systematic computational study proposed <i>Pv</i>puCSP as E3-ubiquitin ligase, and the observed diversity may facilitate adaptation to different ubiquitination-related interactions, though this remains to be experimentally validated.
Authors
- Manoswini Dash
- Veena Pande (ORCID: https://orcid.org/0000-0002-4839-7276)
- Abhinav Sinha (ORCID: https://orcid.org/0000-0003-1900-7686)
- Aparup Das (ORCID: https://orcid.org/0000-0002-4081-5816)
Institutions
- Tulane University (US)
- Kumaun University (IN)
- Regional Medical Research Centre (IN)
- National Institute of Malaria Research (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Current Research in Microbial Sciences
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.crmicr.2025.100432
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Council of Medical Research