The Combination of the Autophagy Inhibitor Chloroquine and Recombinant Methioninase Has Selective Synergistic Efficacy on Human Colon Cancer Cells But Not on Normal Human Fibroblasts
The combination of chloroquine and rMETase had synergistic efficacy on colon-cancer cells, but not on normal fibroblasts. rMETase is used clinically as an oral supplement, and chloroquine is a drug approved for clinical use. Therefore, the combination of rMETase and chloroquine has the potential for safe clinical application.
Authors
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- Norio Yamamoto (ORCID: https://orcid.org/0000-0002-7902-9994)
- SHUKUAN LI
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-2896-4939)
- Hiroyuki Tsuchiya (ORCID: https://orcid.org/0000-0003-0730-7921)
- KOHEI MIZUTA
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0002-1847-3741)
- Hiroaki Kimura (ORCID: https://orcid.org/0000-0003-2145-8726)
- Satoru Demura
- Robert M. Hoffman
- Qinghong Han
- YUTA MIYASHI
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.21873/anticanres.17651
- Citations
- 2
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.47