The Effect of Staphylococcus aureus Exopolysaccharides of Biofilm Extract on Apoptosis Induction in LNCaP Prostate Cancer Cell Lines

Background: One of the most prevalent solid tumors in men is prostate cancer which is caused by a lack of apoptosis, which leaves cancerous cells that refuse to die.Consequently, triggering apoptosis is a common approach for anticancer treatments to destroy tumor cells.The bacterial biofilm's EPS (Exopolysaccharides) is paying attention as a potential novel cancer treatment source.Methods: This study targeted to determine the anti-cancer capabilities of EPS extract and its impact on the expression of the genes Bcl-2, Bax, p53, caspase3, and caspase9 in the prostate cancer cell line (LNCaP).Results: Treatment of LNCaP cells with EPS extract caused a significant increase in the expression rate of the apoptosis genes and behavior LNCaP cells were driven toward cell death. Conclusion:According to the obtained result the bacterial EPS shows promising results to be considered as an anticancer drug for prostate tumors.