Hepatoprotective Effects of Resveratrol Against Diazinon-Induced Hepatotoxicity: Experiment in Rat

Background: Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, has been suggested as a hepatoprotective agent.Diazinon is an organophosphorus insecticide that causes hepatocellular damage by causing oxidative stress and inflammation.Aim: This study investigates the protective effects of resveratrol against diazinon-induced liver toxicity in laboratory rats.Methods: Five groups of thirty rats were created: (1) diazinon-only, (2-3) resveratrol pre-treatment at varying doses before diazinon, (4) vitamin C pre-treatment before diazinon, and (5) control (distilled water).Oral treatments were given for 30 days.Liver function biomarkers (ALT, AST), oxidative stress indicators (GPx), and inflammatory cytokines (IL-1) were assessed alongside histopathological analysis.Results: Diazinon exposure significantly elevated AST, ALT, IL-1, and liver weight while lowering GPx actions and causing histopathological liver damage.Resveratrol pre-treatment effectively reduced these effects, evidenced by decreased enzyme levels, attenuated inflammation, enhanced antioxidant activity, and improved liver histology. Conclusion:Resveratrol protects against diazinon-induced hepatotoxicity by reducing oxidative stress, inflammation, and liver damage.Its therapeutic potential warrants further investigation for clinical applications against organophosphate-induced liver damage.