Impact of Cisplatin on the Incidence of Nephrotoxicity in Patients at the National Oncology Teaching Hospital in Al-Najaf Province, Iraq

Background: nephrotoxicity is one of the significant complications of cisplatin.Aim of study: to evaluate the impact of cisplatin on nephrotoxicity in patients at the National Oncology Teaching Hospital in Al-Najaf Province.Patients and methods: An observational, cohort study was conducted by 40 patients at the National Hospital for Oncology and Hematology in Al-Najaf Al-Ashraf, Iraq. Results:The study shows significant differences in urea and creatinine levels before and after cisplatin treatment with p-values of 0.381, 0.036, respectively.Cisplatin treatment significantly increased urea and creatinine levels in both genders, with females experiencing a more pronounced decrease after four months than men.Conclusion: Our findings indicate a high incidence of nephrotoxicity in Cisplatin patients, with males at greater risk than females.This is influenced by Urea and Creatinine levels before, 2 months after, and 4 months after Cisplatin treatment.