CCR1hi/CCL5hi macrophage-mediated CCL5hi T cell chemotaxis in salivary gland aggravates Sjögren’s syndrome
We revealed that CCR1<sup>hi</sup>/CCL5<sup>hi</sup> macrophages-mediated recruitment and activation of CCL5<sup>hi</sup> T cells and B cells in salivary glands aggravate SS pathogenesis, suggesting CCR1/CCL5 as a novel target to treat SS.
Authors
- X. Chen (ORCID: https://orcid.org/0009-0000-0162-725X)
- Danli Xiao
- Jiang Li (ORCID: https://orcid.org/0009-0005-6253-618X)
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Z. Pan
- Lijing Wang
- Danyang Liu (ORCID: https://orcid.org/0000-0003-3875-1822)
- Nobumoto Watanabe (ORCID: https://orcid.org/0000-0002-2130-1334)
- Jiannan Zhou (ORCID: https://orcid.org/0009-0004-5023-8989)
Institutions
- Tokyo Medical and Dental University (JP)
- Guangdong Pharmaceutical University (CN)
- Stomatology Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.jare.2025.06.076
- Citations
- 6
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Natural Science Foundation of China
- Guangzhou Science and Technology Program key projects
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research