Aryl hydrocarbon receptor impairs HK2-controlled flux of the hexosamine biosynthesis pathway to suppress NETosis in an N-glycosylation-dependent manner
AhR activation suppresses NETosis by modulating HK2-mediated HBP flux and the subsequent N-glycosylation of AAT and A2M, thereby decreasing NE activity.
Authors
- Zhifeng Wei (ORCID: https://orcid.org/0000-0002-9246-9783)
- Yue Dai (ORCID: https://orcid.org/0000-0003-4872-2064)
- Yang Li (ORCID: https://orcid.org/0000-0002-7134-5685)
- Jie Song (ORCID: https://orcid.org/0000-0002-5685-9741)
- Shijia Li (ORCID: https://orcid.org/0000-0002-8813-7815)
- Jingchao Zhu
- Y.-H. Gong
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.jare.2025.06.078
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80