Structural and causal links between retinal vascular geometry and neural layer thickness
GC-IPL and INL were positively associated with vascular Density and Caliber. Multidimensional relationships indicate a complementary nature between retinal vascular and neural parameters, highlighting their value as a composite biomarker. Mendelian Randomization uncovered a bidirectional causal relationship, providing insights into novel therapeutic approaches targeting vascular and neuronal components.
Authors
- Algis J. Vingrys (ORCID: https://orcid.org/0000-0001-5920-4604)
- Mingguang He (ORCID: https://orcid.org/0000-0002-6912-2810)
- Danli Shi (ORCID: https://orcid.org/0000-0001-6094-137X)
- Robert Neal Weinreb (ORCID: https://orcid.org/0000-0001-9553-3202)
- Mayinuer Yusufu (ORCID: https://orcid.org/0000-0002-4860-0318)
- Xianwen Shang (ORCID: https://orcid.org/0000-0001-6143-9349)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-2343-084X)
- Meng‐Tian Kang
Institutions
- Beijing Tongren Hospital (CN)
- Hong Kong Polytechnic University (HK)
- Capital Medical University (CN)
- Centre for Eye Research Australia (AU)
- The California Eye Institute (US)
Publication Details
- Journal
- Microvascular Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.mvr.2025.104834
- Citations
- 4
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- University of Melbourne
- State Government of Victoria