Calcium binding by γ-carboxyglutamic acid: it takes two to tether
Vitamin K-dependent proteins present Gla residues in a different manner but benefit from cooperative calcium ion binding. Experimentally determined p<i>K</i> <sub>a</sub> and <i>K</i> <sub>D</sub> values can be used for interpretation of binding interactions or for molecular dynamics simulations of Gla domains with unknown structure.
Authors
- Tilman M. Hackeng (ORCID: https://orcid.org/0000-0003-0142-0843)
- Stijn M. Agten (ORCID: https://orcid.org/0000-0002-5973-272X)
- Hans Ippel (ORCID: https://orcid.org/0000-0001-6589-6678)
- Sem J Peijnenborgh
Institutions
- Maastricht University (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.rpth.2025.102964
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Society on Thrombosis and Haemostasis
- Hartstichting