The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation
This study employed scRNA-seq and multi-omics analysis to elucidate the pathogenesis of BAVM, uncovering the key role of ATF3 in ECs proliferation. Targeting ATF3 provided a new possibility for the treatment of BAVM and also made up for the blank of ATF3 in the exploration of BAVM. This study provided a theoretical basis for the personalized treatment of BAVM and demonstrated the potential of scRNA-seq and multi-omics methods in advancing precision medicine.
Authors
- Nan Wu (ORCID: https://orcid.org/0000-0002-1475-4503)
- Jiwei Ma (ORCID: https://orcid.org/0000-0001-7799-8807)
- Xiangyang Wang (ORCID: https://orcid.org/0000-0002-6504-2661)
- Lei Meng
- Shupeng Zhao
- Jiyu Ji
- Lei Sun (ORCID: https://orcid.org/0000-0001-5216-0354)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1567970
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00