The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation

This study employed scRNA-seq and multi-omics analysis to elucidate the pathogenesis of BAVM, uncovering the key role of ATF3 in ECs proliferation. Targeting ATF3 provided a new possibility for the treatment of BAVM and also made up for the blank of ATF3 in the exploration of BAVM. This study provided a theoretical basis for the personalized treatment of BAVM and demonstrated the potential of scRNA-seq and multi-omics methods in advancing precision medicine.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-06-27
DOI
https://doi.org/10.3389/fimmu.2025.1567970
Primary Topic
Vascular Malformations Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation

Nan Wu, Jiwei Ma, Xiangyang Wang, Lei Meng et al.
Frontiers in Immunology
Vascular Malformations Diagnosis and Treatment
article

The role of ATF3 in precision medicine of brain arteriovenous malformation: based on endothelial cell proliferation

Nan Wu, Jiwei Ma, Xiangyang Wang, Lei Meng, Shupeng Zhao, Jiyu Ji, Lei Sun
article en

Abstract

This study employed scRNA-seq and multi-omics analysis to elucidate the pathogenesis of BAVM, uncovering the key role of ATF3 in ECs proliferation. Targeting ATF3 provided a new possibility for the treatment of BAVM and also made up for the blank of ATF3 in the exploration of BAVM. This study provided a theoretical basis for the personalized treatment of BAVM and demonstrated the potential of scRNA-seq and multi-omics methods in advancing precision medicine.

Frontiers in ImmunologyVol. 16
Shandong University of Traditional Chinese Medicine (CN), First Affiliated Hospital of Xinxiang Medical University (CN)
Good health and well-being
Openalex Percentile: Top 76%
Vascular Malformations Diagnosis and Treatment
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