Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor
We elucidate a novel redox-dependent regulatory mechanism governing the nuclear localisation of PIR and its role in promoting liver inflammation and HCC progression. Our findings underscore the significance of cellular redox status in regulating PIR's activity and highlight the potential of targeting this pathway with antioxidants to mitigate HCC progression.
Authors
- Furong Lin (ORCID: https://orcid.org/0000-0001-5732-6253)
- Fengqiong Zhang
- Jun A You (ORCID: https://orcid.org/0000-0003-1977-3671)
- Huanhuan Ma (ORCID: https://orcid.org/0000-0001-8029-6814)
- Yanming Zhou (ORCID: https://orcid.org/0000-0002-8684-7485)
- Xiyao Liu (ORCID: https://orcid.org/0000-0002-1366-3239)
- Yao Lin (ORCID: https://orcid.org/0000-0002-0493-0155)
- Bin Jiang (ORCID: https://orcid.org/0000-0002-1156-2557)
- Yuxin Liu
- Qinxi Li (ORCID: https://orcid.org/0000-0002-7275-4595)
- Tingyan Cao
- Lili Chen (ORCID: https://orcid.org/0000-0001-5485-718X)
- Yue Wang (ORCID: https://orcid.org/0000-0001-6936-5081)
- Jinyang Wang (ORCID: https://orcid.org/0000-0002-2517-7473)
- Weiling He (ORCID: https://orcid.org/0000-0003-4061-7382)
- Dachao Sun (ORCID: https://orcid.org/0000-0002-3307-6592)
- SW Lai
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1136/gutjnl-2024-334087
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Fujian Province
- Basic and Applied Basic Research Foundation of Guangdong Province