Association of cortisol levels with psychopathological features of depression and therapeutic response in female patients
In patients with depression, the prevalence of hypothalamic-pituitary-adrenal (HPA) axis dysfunction is higher than in the general population. HPA axis dysfunction appears to be associated with psychomotor retardation, adynamia, agitation, and anhedonia. The lack of cortisol inhibition in LDDST is the most reliable laboratory marker of a low-curable depressive state. Absolute treatment resistance in depression is associated with HPA axis dysfunction.
Authors
- И. В. Олейчик (ORCID: https://orcid.org/0000-0002-8344-0620)
- I. N. Otman (ORCID: https://orcid.org/0000-0003-3745-8413)
- S. A. Zozulya (ORCID: https://orcid.org/0000-0001-5390-6007)
- Е. Г. Старостина (ORCID: https://orcid.org/0000-0002-3328-2812)
- П. А. Баранов (ORCID: https://orcid.org/0000-0002-4423-4007)
- Elena Przhiyalkovskaya (ORCID: https://orcid.org/0000-0001-9119-2447)
- O. A. Yunilainen
- Yu. A. Chaika (ORCID: https://orcid.org/0000-0001-7182-2472)
Institutions
- Centre for Mental Health (GB)
- Regional Clinical Research (US)
Publication Details
- Journal
- S S Korsakov Journal of Neurology and Psychiatry
- Published
- 2025-06-27
- DOI
- https://doi.org/10.17116/jnevro202512506145
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11