A Low-Power Wireless Optical SoC for Fluorescence Monitoring

This paper presents a low-power, optical systemon-chip (SoC) enabling wireless fluorescence detection. The proposed SoC, in size of 2 × 2.7 mm<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>, integrates a high-sensitivity optical front-end, battery management unit and energy harvesting, and a wireless data transceiver. A fast-settling transimpedance amplifier (TIA) ensures rapid startup and minimizes power consumption, supported by dual-mode low dropout regulators (LDO regulators) for efficient power management. The SoC achieves ultra-low power, 1 μW, operation with 0.5 pA sensitivity, suitable for non-invasive cellular monitoring. The SoC is implemented using 65 nm CMOS technology.