Deep Brain Neurostimulation Through Engineered Circular Spiral Micro-Coils

In the realm of neurostimulation, magnetic techniques have emerged as a promising modality for both fundamental neuroscience investigations and the clinical management of neurological disorders, potentially surpassing the limitations associated with conventional electrical stimulation. This study investigated the feasibility of spiral µ-coils for magnetic neurostimulation, employing both computational modeling and experimental validation. Computational modeling demonstrated that varying current amplitudes (1-5 A) across the tested frequency range resulted in average magnetic (B) flux densities ranging from 8.41 to 42.05 mT, sufficient to achieve a neurostimulation depth of approximately 2 cm within the model. Experimental optimisation identified a laser cutting power of 2.6 W. Corresponding measurements of the B-field revealed a spatial gradient, with values ranging from 1.72 µT at the coil's center to 772.26 nT at a radial distance of 25 mm. These results indicate the potential of magnetic neurostimulation for modulating neural activity in subcortical brain regions.