Effects of DA-9701 (motilitone®) on gastric emptying, glycemic control, and oxidative stress in diabetic rats
DA-9701 normalized gastric emptying and glycemic control while reducing the expression of ERK1/2, c-Kit, and PCNA, which are elevated in diabetic gastric tissues. These findings highlight the dual therapeutic potential of DA-9701 in regulating both gastrointestinal motility and glycemic variability in diabetes, warranting further investigation in clinical settings.
Authors
- Juhee Kim
- Minjun Kim (ORCID: https://orcid.org/0000-0002-3236-9238)
- Kyung Jae Yoon (ORCID: https://orcid.org/0000-0002-2765-4309)
- Chong Il Sohn (ORCID: https://orcid.org/0000-0002-9748-8537)
- Yurim Hong (ORCID: https://orcid.org/0000-0002-2570-9337)
- Jung Ho Park (ORCID: https://orcid.org/0000-0002-8367-4371)
- Yookyung Kim (ORCID: https://orcid.org/0000-0002-7247-7815)
- Young Mi Song
Institutions
- Kangbuk Samsung Hospital (KR)
- Chung-Ang University Hospital (KR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1371/journal.pone.0316686
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- National Research Foundation of Korea