Metabolism-based scoring of cutaneous squamous cell carcinoma to predict tumour features and responses to treatment with dihydroorotate dehydrogenase inhibitors
The findings demonstrate the relevance of metabolic profiling and scoring in the design of therapeutic approaches targeting the bioenergetic vulnerabilities of tumours and suggest DHODH as a promising therapeutic target in the low metabolic score subgroup of cSCC.
Authors
- M. Beylot‐Barry (ORCID: https://orcid.org/0000-0001-6150-1229)
- Benoı̂t Rousseau (ORCID: https://orcid.org/0000-0002-1594-4827)
- B. Vergier (ORCID: https://orcid.org/0000-0002-3498-3143)
- Domitille Chalopin-Fillot
- Elodie Muzotte (ORCID: https://orcid.org/0000-0002-1721-940X)
- M. Bondaz (ORCID: https://orcid.org/0000-0001-6106-5789)
- Laure Favot (ORCID: https://orcid.org/0000-0001-7642-3550)
- Nívea Dias Amoêdo (ORCID: https://orcid.org/0000-0002-8666-6430)
- Walid Mahfouf
- Alain Taı̈eb (ORCID: https://orcid.org/0000-0002-0928-8608)
- Benjamin Dartigues (ORCID: https://orcid.org/0000-0003-1882-123X)
- Fatima Naji
- Stéphane Claverol (ORCID: https://orcid.org/0000-0001-5315-2823)
- Macha Nikolski (ORCID: https://orcid.org/0000-0001-6059-577X)
- Rodrigue Rossignol (ORCID: https://orcid.org/0000-0002-8983-2465)
- Marie‐Laure Jullié (ORCID: https://orcid.org/0000-0002-0048-6501)
- L. Dousset (ORCID: https://orcid.org/0000-0002-5332-5736)
- Fanny Beltzung (ORCID: https://orcid.org/0009-0006-1202-0019)
- Ferial Khalife
- Hamid-Reza Revani
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Services déconcentrés d'appui à la recherche Nouvelle-Aquitaine-Bordeaux (FR)
- Bordeaux Population Health (FR)
- Hôpital Saint-André (FR)
- Laboratory of Research in Fluid Dynamics and Combustion Technologies (ES)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Institut de Biochimie et Génétique Cellulaires (FR)
- Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers (FR)
- Institut de Génomique Fonctionnelle (FR)
- Maladies Rares: Génétique et Métabolisme (FR)
- BoRdeaux Institute of onCology (FR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1093/bjd/ljaf253
- Citations
- 1
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation ARC pour la Recherche sur le Cancer
- Société Française de Dermatologie et de Pathologie Sexuellement Transmissible
- Université de Bordeaux
- Institut National Du Cancer