2-Hydroxychalcone attenuates airway inflammation, oxidative stress, and NF-κB activation in ovalbumin-induced asthma model
Our findings showed that 2HC is anti-inflammatory and antioxidant, suggesting that it may be useful in treating asthma by blocking NF-κB activation.
Authors
- Hadeer Hesham Abdelfattah
- Mohamed A. Kotb (ORCID: https://orcid.org/0009-0008-4169-1967)
- Lamiaa Goda
- Ahmed M. Sayed (ORCID: https://orcid.org/0000-0002-1442-183X)
- Noha A. Mahana (ORCID: https://orcid.org/0000-0001-7905-7787)
- Abeer Mahmoud Badr (ORCID: https://orcid.org/0000-0003-3503-6639)
- Hamid Ashry
- Ayman Saber Mohamed (ORCID: https://orcid.org/0000-0003-3975-4355)
- Safaa H. El‐Taweel (ORCID: https://orcid.org/0000-0001-5884-6584)
- Islam Ahmed Abdelmawgood (ORCID: https://orcid.org/0009-0006-3836-4098)
- Sohaib Ali Ramadan
- Bahaa Sharaf
- Bassam W Ebeed (ORCID: https://orcid.org/0009-0002-7873-359X)
- Marina Lotfy Khalaf
- Abdessamad El Adel (ORCID: https://orcid.org/0009-0000-4880-8293)
- Merihan Hany Abdelazeem
- Rawan G. Zahran
- Hassan Samy Hassan Eltras
Institutions
- Cairo University (EG)
- St Petersburg University (RU)
- Tanta University (EG)
- Helwan University (EG)
- Theodor Bilharz Research Institute (EG)
Publication Details
- Journal
- Journal of Asthma
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1080/02770903.2025.2526384
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00