Synthesis of Chiral Dispiro‐indolinone‐pyrrolidine‐rhodanines Using (R)/(S)‐1‐(2,4‐dimethoxyphenyl)ethylamine

Abstract The use of (R) or (S)‐1‐(2,4‐dimethoxyphenyl)ethylamines as starting compounds makes it possible to obtain the individual enantiomers of dispiro‐indolinone‐pyrrolidine‐rhodanines with a yield of up to 53% based on a three‐step synthesis through the formation of 5‐arylidenrhodanines with a chiral substituent at N(3) atom, their subsequent 1,3‐dipolar cycloaddition with azomethine ylide generated in situ from isatin and sarcosine and chromatographic separation of the resulting diastereomers.