Advancements In Tumor Microenvironment-Responsive Intelligent Nanomedicine Delivery Systems for Breast Cancer Treatment

Breast cancer severely threatens women's health. Traditional therapeutic approaches face numerous limitations, including an inability to overcome significant physiological and pathological barriers, as well as notable toxic side effects. Tumor microenvironment-responsive intelligent nanomedicine delivery systems leverage the characteristics of the tumor microenvironment to deliver drugs, offering new hope for breast cancer treatment. This article comprehensively reviews the research progress of these systems in breast cancer therapy, including the characteristics of the tumor microenvironment, design principles of various responsive nanomedicine delivery systems, application examples, and future directions for development.