Research in mRNA vaccines and delivery carriers

Nowadays, mRNA vaccine in medicine, biology, chemistry and other fields play a huge role, but after decades of research, mRNA vaccine still has not been widely used, this is because mRNA vaccine stability is poor, easy to serumRNA hydrolase degradation, or by monocytic-macrophage system and unable to reach the target cells play a role. Moreover, the mRNA has a relatively large molecular mass and a negative charge, making it difficult to penetrate the phospholipid bilayer and enter the cell membrane, resulting in the decrease of cell permeability. Therefore, it is necessary to design appropriate delivery systems to ensure the smooth entry of mRNA into the target cells and the effective release into the cytoplasm for translation. This paper reviews the current status and progress of mRNA vaccines, and introduces several different delivery systems, their main roles and examples studied examples, and prospects the infinite potential of AI development on mRNA drugs.