Co-occurrence of myositis and neuropathy after anti-CD30 therapy in a late-adolescent Hodgkin lymphoma patient
Myositis following BV therapy has not been reported. Findings suggest an immune-mediated mechanism with B-cell involvement. Given the response to IVIG, B-cell-directed therapies may be beneficial. This case identifies BV-induced myositis as a novel irAE.
Authors
- Tim Hagenacker (ORCID: https://orcid.org/0000-0002-3631-3450)
- Ulrike Schara‐Schmidt (ORCID: https://orcid.org/0000-0001-5833-2751)
- Andreas Hentschel (ORCID: https://orcid.org/0000-0002-0272-9220)
- Tobias Ruck (ORCID: https://orcid.org/0000-0001-6332-8650)
- Adela Della Marina (ORCID: https://orcid.org/0000-0003-0737-6142)
- Heike Kölbel (ORCID: https://orcid.org/0000-0001-9629-7053)
- Vera Dobelmann
- Michael M. Schündeln (ORCID: https://orcid.org/0000-0001-7495-9060)
- Andreas Roos
- Christopher Nelke (ORCID: https://orcid.org/0000-0002-6633-982X)
- Teresinha Evangelista
- Lydia Rink (ORCID: https://orcid.org/0009-0004-9942-3819)
- Calvin Tucht
Institutions
- University of Ottawa (CA)
- Inserm (FR)
- Children's Hospital of Eastern Ontario (CA)
- Sorbonne Université (FR)
- Düsseldorf University Hospital (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Myologie (FR)
- Essen University Hospital (DE)
- Leibniz Institute for Analytical Sciences - ISAS (DE)
- Pitié-Salpêtrière Hospital (FR)
- BG University Hospital Bergmannsheil Bochum (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1186/s40478-025-02056-2
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitätsklinikum Essen
- Universität Duisburg-Essen
- Deutsche Gesellschaft für Muskelkranke
- Stiftung Universitätsmedizin Essen
- Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
- European Regional Development Fund