Predictors of treatment response and overall survival in patients with breast cancer brain metastases treated with stereotactic radiosurgery: a prospective study using the NeuroPoint Alliance SRS Registry
Using real-world data from the NPA SRS Registry, this study demonstrated comparable outcomes in patients who underwent SRS for breast cancer brain metastases compared with those of previous literature. The number of lesions at the time of SRS and the marginal dose were independent risk factors for local recurrence, out-of-field progression, and overall intracranial progression. Pre-SRS resection and baseline EQ-5D score were independent predictors of quality of life following SRS.
Authors
- Nader Pouratian (ORCID: https://orcid.org/0000-0002-0426-3241)
- Konstantinos Katsos
- Mohamad Bydon (ORCID: https://orcid.org/0000-0002-0543-396X)
- Jason P. Sheehan (ORCID: https://orcid.org/0000-0002-4763-7346)
- Eric L. Chang (ORCID: https://orcid.org/0000-0003-2708-6724)
- David W. Andrews (ORCID: https://orcid.org/0000-0002-9266-7157)
- Robert Timmerman (ORCID: https://orcid.org/0000-0003-2462-1007)
- Randy L. Jensen (ORCID: https://orcid.org/0000-0002-2824-4221)
- James McInerney (ORCID: https://orcid.org/0000-0001-8071-369X)
- Kevin A. Walter
- Giorgos D. Michalopoulos (ORCID: https://orcid.org/0000-0002-7473-7262)
- Anthony L. Asher (ORCID: https://orcid.org/0000-0002-3596-3849)
- Anthony D’Ambrosio
- Albert Attia
- William S. Cobb
- Aaron C. Spalding
- Inga S. Grills
Institutions
- University of Southern California (US)
- Mayo Clinic (US)
- Carolinas Healthcare System (US)
- Lebanon Valley College (US)
- Norton Healthcare (US)
- University of Utah (US)
- Thomas Jefferson University Hospital (US)
- Beaumont Health (US)
- University of Virginia Health System (US)
- Valley Hospital (US)
- Jacksonville College (US)
- University of Rochester Medical Center (US)
- Carolina Neurosurgery and Spine Associates (US)
- Southwestern Medical Center (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
- Southwestern Medical Center (US)
- Penn State Milton S. Hershey Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-06-27
- DOI
- https://doi.org/10.3171/2025.3.jns241471
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00