Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair
This study presents a safe and effective direct reprogramming strategy for skin regeneration, bypassing the pluripotent stage and avoiding cell transplantation. The B2 combination provides a novel molecular tool for wound repair and offers translational potential for treating non-healing wounds such as DFUs.
Authors
- Yuhuai Hu
- Bo Yang (ORCID: https://orcid.org/0000-0003-4608-6957)
- Zizheng Gao
- Zhifei Xu (ORCID: https://orcid.org/0000-0002-1896-097X)
- Peihua Luo (ORCID: https://orcid.org/0000-0002-6576-2052)
- Huilin Ma (ORCID: https://orcid.org/0000-0003-4238-9475)
- Qiaojun He (ORCID: https://orcid.org/0000-0002-0104-6989)
- Yashi Cao
Institutions
- Zhejiang University (CN)
Publication Details
- Journal
- Stem Cell Reviews and Reports
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1007/s12015-025-10929-1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China