Nine autochthonous cases of Toscana virus infection in France, 2022–2024: a clinical and virological overview
This study confirms the continued circulation of Toscana virus (TOSV) lineage B in France, with nine laboratory-confirmed autochthonous neuroinvasive cases identified between 2022 and 2024. All patients presented with central nervous system symptoms, predominantly during summer months, and most were confirmed by RT-qPCR (quantitative reverse transcription polymerase chain reaction) on cerebrospinal fluid. Phylogenetic analysis revealed close similarity to previously circulating French strains, supporting long-term local transmission. One case in eastern France raises concern for possible geographic expansion. These findings underscore the need for sustained surveillance and preventive measures in endemic regions, particularly for travellers and clinicians encountering summer-onset neurological syndromes.
Authors
- Gilda Grard (ORCID: https://orcid.org/0000-0002-6088-2581)
- Rémi N. Charrel (ORCID: https://orcid.org/0000-0002-7675-8251)
- Laura Pezzı (ORCID: https://orcid.org/0000-0001-7921-9221)
- S. Bayle
- Guillaume André Durand (ORCID: https://orcid.org/0000-0003-3348-9618)
- Läétitia Ninove (ORCID: https://orcid.org/0000-0002-3213-6282)
- Antoine Nougaırède (ORCID: https://orcid.org/0000-0001-7729-2636)
- Xavier Nicolas de Lamballerie (ORCID: https://orcid.org/0000-0001-7895-2720)
- Raphaëlle Klitting (ORCID: https://orcid.org/0000-0002-7777-0308)
- Léa Lucıanı (ORCID: https://orcid.org/0000-0002-0738-5957)
- Nazlı Ayhan (ORCID: https://orcid.org/0000-0003-4979-6794)
- Nadim Cassir (ORCID: https://orcid.org/0000-0002-5276-6986)
- Julie Allemand
- Anne Darmon
- A. Chollet
- Elif Kurum
- Fabrice Edorh
- Jean Sélim Drıouıch
Institutions
- Inserm (FR)
- Aix-Marseille Université (FR)
- Olea Medical (France) (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Hydrogen Fuel Cells and Electro-Mobility in European Regions (BE)
- Laboratoire Informatique d'Avignon (FR)
- Centre Hospitalier Edmond Garcin (FR)
Publication Details
- Journal
- Journal of Travel Medicine
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1093/jtm/taaf057
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aix-Marseille Université
- UK Research and Innovation
- European Commission