Strengthening radiation response and expanding cytogenetic applications: Indian biodosimetry network (IN-BioDoS)

As nuclear energy and radiation applications expand, advancing biodosimetry is crucial for assessing radiation exposure, especially during radiological emergencies. The Bhabha Atomic Research Centre's (BARC) Biodosimetry Laboratory has pioneered dose estimation techniques, including dicentric chromosome assay, cytokinesis block micronucleus assay, Chromosomal translocation by fluorescence<i>in situ</i>hybridisation,<i>γ</i>H2AX, 53BP1, and premature chromosome condensation. To enhance preparedness, BARC has launched the Indian biodosimetry network, integrating cytogenetic with an aim to standardise methods, promote collaboration, and ensure accurate dose assessments through inter-laboratory comparisons. Future expansions, including rapid biodosimetry techniques and global partnerships, will strengthen the handling of radiation emergencies. These techniques also hold potential in clinical diagnostics, personalised medicine, and drug testing, reinforcing societal applications in medical care.