Amomaxyz A and B, Sesquiterpene-Indole Alkaloids from Fruits of <i>Amomum maximum</i> Roxb
Two unprecedented 4/9/5-membered ring sesquiterpene-indole alkaloids, amomaxyz A (<b>1</b>) and B (<b>2</b>), along with one known compound caryolane-1,9β-diol (<b>3</b>), were isolated from the fruit of <i>Amomum maximum</i> Roxb. Their structures and absolute configurations were elucidated through comprehensive spectroscopic analyses, including NMR, electronic circular dichroism (ECD), X-ray single-crystal diffraction, and DP4 probability analysis of calculated NMR data. Biological evaluation revealed distinct anti-inflammatory and anticancer activities. <b>1</b> demonstrated dose-dependent anti-inflammatory activity by suppressing NO release in LPS/IFN-γ-activated RAW264.7 macrophages (25.9% at 10 μM, 29.9% at 20 μM; <i>P</i> < 0.01), while <b>2</b> and <b>3</b> exhibited weaker effects. Moreover, <b>1</b> (IC<sub>50</sub> = 30.62 μM) and <b>2</b> (IC<sub>50</sub> = 23.43 μM) showed moderate inhibitory effects against HepG2 cells, which reveals the potential of their biological activity.
Authors
- Jin‐Na Zhao
- Xianmei Piao (ORCID: https://orcid.org/0000-0003-1360-7234)
- Li-Bo Wang
- Y. D. Qu
- Bo Li (ORCID: https://orcid.org/0000-0003-0022-0583)
- Jinhui Wang
- Ze Li (ORCID: https://orcid.org/0000-0003-4179-8672)
- Lu Chen
- Jian Huang (ORCID: https://orcid.org/0000-0002-5621-488X)
- Shufei Yu
- M. He (ORCID: https://orcid.org/0009-0000-8346-5716)
- Zhihang Wu (ORCID: https://orcid.org/0009-0008-7854-4100)
- Yanjun Ding (ORCID: https://orcid.org/0000-0001-9747-8112)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00539
- Citations
- 3
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- Harbin Medical University