An FDG-PET–Based Machine Learning Framework to Support Neurologic Decision-Making in Alzheimer Disease and Related Disorders
Our proposed framework provides strong classification performance with high interpretability, and it addresses many of the challenges that face clinical integration of ML-based decision support tools. One limitation of this study is a uniform discovery cohort that is not representative of other patient populations in some regards.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Ellen Dicks (ORCID: https://orcid.org/0000-0003-2496-1626)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Derek Richard Johnson (ORCID: https://orcid.org/0000-0002-4217-5517)
- John L. Stricker
- Sean J. Huls (ORCID: https://orcid.org/0000-0001-8741-5425)
- Nick Corriveau‐Lecavalier (ORCID: https://orcid.org/0000-0002-6561-9870)
- Brian J. Burkett (ORCID: https://orcid.org/0000-0002-0457-5712)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Hugo Botha (ORCID: https://orcid.org/0000-0003-4390-685X)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Aivi T. Nguyen (ORCID: https://orcid.org/0000-0003-1809-9451)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Leland Barnard
- Hoon‐Ki Min (ORCID: https://orcid.org/0000-0002-1084-2469)
- Aditya Khurana (ORCID: https://orcid.org/0000-0001-9148-9531)
- Gemeng Zhang (ORCID: https://orcid.org/0000-0001-6223-6092)
- Robert Ross Reichard (ORCID: https://orcid.org/0000-0003-0842-2462)
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
- Winnie Z. Fan (ORCID: https://orcid.org/0009-0000-7193-4132)
- Venkatsampath Gogineni
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Jacksonville College (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1212/wnl.0000000000213831
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24