Improved Survival From Graft-versus-host Disease Following Pediatric Small Intestinal Transplantation Through Reduction in Systemic Immunosuppression Altering T-cell Chimerism Dynamics
Our results demonstrate that that altering the immunosuppressive therapy strategy, following clinical manifestations of GvHD such as a typical skin rash, from intensification to a reduction in immunosuppression led to significantly improved survival.
Authors
- Darius F. Mirza (ORCID: https://orcid.org/0000-0002-7531-9089)
- Jane Hartley (ORCID: https://orcid.org/0000-0002-4201-6460)
- Shyla Kishore
- Arun Alfred
- Girish Gupte (ORCID: https://orcid.org/0000-0002-9026-1583)
- Malobi Ogboli (ORCID: https://orcid.org/0000-0002-8861-6998)
- Sandeep Potluri (ORCID: https://orcid.org/0000-0001-7229-5344)
- Sarah Lawson (ORCID: https://orcid.org/0000-0002-0514-8077)
- Khalid Sharif (ORCID: https://orcid.org/0000-0002-9722-6326)
- Yvonne Wilson
Institutions
- The Rotherham NHS Foundation Trust (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1097/txd.0000000000001830
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00