Pain, fatigue, and associated gene expressions over chemotherapy in patients with colorectal cancer
These findings suggest inflammation and specific biomarkers may drive pain and fatigue during chemotherapy. Further preclinical models or clinical cohorts are needed to validate these results and explore potential implications for targeted interventions to reduce symptom burden in patients with colorectal cancer.
Authors
- Wanli Xu
- Andrew Salner (ORCID: https://orcid.org/0000-0002-3145-2953)
- Xiaomei Cong (ORCID: https://orcid.org/0000-0002-4992-199X)
- Weizi Wu (ORCID: https://orcid.org/0000-0002-1885-7198)
- Michelle Judge (ORCID: https://orcid.org/0000-0002-8318-7311)
- Vijender Singh (ORCID: https://orcid.org/0000-0002-9382-269X)
- Ming‐Hui Chen (ORCID: https://orcid.org/0000-0003-1935-2447)
- Aolan Li
Institutions
- Hartford Hospital (US)
- University of Connecticut (US)
- Yale University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1371/journal.pone.0325849
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sigma Theta Tau International
- Oncology Nursing Foundation