Filling in the Gaps of Examining Human Epidermal Growth Factor Receptor 2 (HER2)–Low and HER2-Ultralow in Breast Cancer: Clone Choice, Sample Size, and Reevaluating Scores Made on Archived Samples
The discordance of HER2 staining depended on the sample size and antibody clone. Tissue stained with 4B5 (CNB or EB), but not with CNB-HercepTest, correlated with mRNA values.
Authors
- Sayeeda Yasmeen
- Emad Alqassim (ORCID: https://orcid.org/0000-0003-0765-7569)
- Thaer Khoury (ORCID: https://orcid.org/0000-0002-8112-6590)
- John Lewis Etter (ORCID: https://orcid.org/0000-0002-4288-3759)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2025-06-27
- DOI
- https://doi.org/10.5858/arpa.2024-0334-oa
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00