Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study
Genetically predisposed individuals have a substantially higher risk of hypertriglyceridaemia when they also have steatotic liver disease. This gene-environment interaction might contribute to more personalised treatment approaches, which require further exploration in future studies.
Authors
- Zhewen Ren (ORCID: https://orcid.org/0009-0008-0065-4529)
- Anke Wesselius (ORCID: https://orcid.org/0000-0003-4474-9665)
- M. Eline Kooi (ORCID: https://orcid.org/0000-0001-7562-5724)
- Alfons J.H.M. Houben (ORCID: https://orcid.org/0000-0002-1747-8452)
- Coen D.A. Stehouwer (ORCID: https://orcid.org/0000-0001-8752-3223)
- Pieter C. Dagnelie (ORCID: https://orcid.org/0000-0003-1767-8814)
- Tos T. J. M. Berendschot (ORCID: https://orcid.org/0000-0002-8101-939X)
- Marleen M. J. van Greevenbroek (ORCID: https://orcid.org/0000-0002-2989-1631)
- Martijn C.G.J. Brouwers (ORCID: https://orcid.org/0000-0002-8229-3331)
- Abraham A. Kroon (ORCID: https://orcid.org/0000-0001-7750-8249)
Institutions
- Maastricht University (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1007/s00125-025-06479-3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00