Clinical phenotypes and renal outcomes in PLA2R-associated membranous nephropathy: a multi-center cohort study with unsupervised cluster analysis
Unsupervised clustering identified distinct clinical phenotypes in PLA2R-positive MN, each associated with different renal prognoses. Phenotype-based risk stratification could enhance treatment precision, improve patient outcomes, and potentially reduce treatment-related adverse effects.
Authors
- Lisa E. Vaughan (ORCID: https://orcid.org/0000-0002-5159-7738)
- Benjamin Wooden (ORCID: https://orcid.org/0000-0003-4286-5005)
- Jing Miao (ORCID: https://orcid.org/0000-0003-0642-9740)
- Andrew S. Bomback (ORCID: https://orcid.org/0000-0001-5449-1667)
- Ladan Zand (ORCID: https://orcid.org/0000-0001-5812-9809)
- Montserrat M. Díaz Encarnación (ORCID: https://orcid.org/0000-0001-5172-3370)
- Jaleh Zand (ORCID: https://orcid.org/0009-0001-9934-385X)
- Luis Fernando Quintana (ORCID: https://orcid.org/0000-0001-7582-8476)
- Shane A. Bobart (ORCID: https://orcid.org/0000-0001-6830-0948)
- María José Soler (ORCID: https://orcid.org/0000-0003-3621-0766)
- Fernando C. Fervenza (ORCID: https://orcid.org/0000-0002-9952-209X)
- Wisit Cheungpasitporn
- Charat Thongprayoon
Institutions
- Universitat Autònoma de Barcelona (ES)
- Mayo Clinic (US)
- Vall d'Hebron Institut de Recerca (ES)
- Methodist Hospital (US)
- Hospital Clínic de Barcelona (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Puigvert Foundation (ES)
- Mayo Clinic in Florida (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Columbia University (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1093/ndt/gfaf107
- Citations
- 3
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 4.29