Impact of Estrogen Replacement on Endothelial Dysfunction and Psychological Health in Women With Hypothalamic Amenorrhea
In women with FHA, 12 weeks of transdermal E2 increased serum E2 levels but did not improve vascular or psychological health measures. Further studies with larger sample sizes and longer follow-up are needed to explore the long-term effects of E2 therapy on cardiovascular and mental health outcomes in this population.
Authors
- Prediman K. Shah (ORCID: https://orcid.org/0000-0002-6351-8291)
- Sarah L. Berga (ORCID: https://orcid.org/0000-0003-1885-0401)
- Margareta D. Pisarska (ORCID: https://orcid.org/0000-0003-1096-6506)
- Mariam Saadedine
- Chrisandra Shufelt (ORCID: https://orcid.org/0000-0001-6886-9210)
- JoAnn E. Manson (ORCID: https://orcid.org/0000-0002-9426-7595)
- Jenna Maughan
- Galen Cook‐Wiens (ORCID: https://orcid.org/0000-0003-4088-6240)
- Stephanie S. Faubion (ORCID: https://orcid.org/0000-0001-9341-7726)
- C. Noel Bairey Merz (ORCID: https://orcid.org/0000-0002-9933-5155)
- Nancy Safwan (ORCID: https://orcid.org/0009-0006-5520-1813)
Institutions
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- Mayo Clinic (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Cedars-Sinai Smidt Heart Institute (US)
- Mayo Clinic in Florida (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1210/clinem/dgaf364
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70