Naproxen in High-Temperature Neoplastic Fever: A Case Report Highlighting Its Distinctive Profile among Nonsteroidal Anti-Inflammatory Drugs

This case underscores the importance of NF in cancer patients with persistent high-grade fevers who are unresponsive to antimicrobial and standard antipyretic therapies and further demonstrates the distinctive efficacy of naproxen in managing such fevers compared with conventional NSAIDs. Specifically, the rapid and sustained defervescence observed following naproxen administration not only supported the diagnosis but also facilitated the timely continuation of anticancer treatment. Therefore, early recognition of NF and appropriate use of the naproxen test may help avoid unnecessary interventions and ultimately improve patient outcomes.