Long-term Safety Pharmacology and Musculoskeletal Changes of HMGB1 Box A Gene Therapy in Middle-aged Monkeys
This study indicated that Box A was safe over a 56-week observation period, causing no adverse clinical symptoms. Notably, it mitigated age-associated phenotypes, including improved bone health, lowered blood glucose, and reduced weight gain in perimenopausal monkeys. These results suggest Box A as a safe rejuvenation medicine.
Authors
- Suchinda Malaivijitnond (ORCID: https://orcid.org/0000-0003-0897-2632)
- Nutchanat Suttisan
- Lalitta Suriya-Arunroj (ORCID: https://orcid.org/0000-0001-8522-6778)
- Sakawdaurn Yasom
- Apiwat Mutirangura (ORCID: https://orcid.org/0000-0003-0238-942X)
- Sukanya Jaroenporn (ORCID: https://orcid.org/0000-0001-6447-5265)
- Motee Chimngam
- Tayanee Chundee
Institutions
- Chulalongkorn University (TH)
- Chiang Mai University (TH)
Publication Details
- Journal
- In Vivo
- Published
- 2025-06-27
- DOI
- https://doi.org/10.21873/invivo.13994
- Citations
- 2
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- National Science and Technology Development Agency
- National Research Council of Thailand
- Thailand Science Research and Innovation