Advances in JDM: biomarker and MRI sensitivity, outcomes and steroid management in a Dutch national prospective cohort
This study demonstrates the superior diagnostic sensitivity of Galectin-9 and CXCL10 over CK, the high sensitivity of MRI and the frequent occurrence of refractory disease and flares despite treatment. Reliable predictors are needed to identify patients who can safely taper immunosuppressants versus those needing continued treatment, and who may benefit from targeted therapies initiated upfront.
Authors
- Esther P A H Hoppenreijs
- Marc H.A. Jansen (ORCID: https://orcid.org/0000-0001-6969-8759)
- Femke van Wijk (ORCID: https://orcid.org/0000-0001-8343-1356)
- Judith Wienke (ORCID: https://orcid.org/0000-0002-3835-6374)
- Sylvia Kamphuis (ORCID: https://orcid.org/0000-0002-1964-352X)
- Annet van Royen‐Kerkhof (ORCID: https://orcid.org/0009-0009-6874-4421)
- Saskia R Veldkamp (ORCID: https://orcid.org/0000-0002-1626-353X)
- J. Merlijn van den Berg (ORCID: https://orcid.org/0000-0001-9431-5457)
- Laura van der Griend
- Petra C. E. Hissink Muller (ORCID: https://orcid.org/0000-0003-1610-8721)
- Wineke Armbrust
- Elsbeth Noppers
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Emma Kinderziekenhuis (NL)
- Beatrix Kinderziekenhuis (NL)
- Willem-Alexander Kinderziekenhuis (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Wilhelmina Children's Hospital (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1093/rheumatology/keaf335
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Prinses Beatrix Spierfonds