Medullary Thyroid Cancer Risk and Mortality in Carriers of Incidentally Identified MEN2A <i>RET</i> Variants
In this cohort study, moderate-risk RET variants were most common in incidental cases. The variants were associated with a substantially lower medullary thyroid cancer risk than clinically ascertained cases. This evidence addresses a current knowledge gap, enabling more informed clinical decision-making.
Authors
- Katherine S. Ruth (ORCID: https://orcid.org/0000-0003-4966-9170)
- Uyenlinh L. Mirshahi (ORCID: https://orcid.org/0000-0003-4972-5451)
- Luke N Sharp (ORCID: https://orcid.org/0009-0001-3657-5493)
- Caroline F. Wright (ORCID: https://orcid.org/0000-0003-2958-5076)
- Bijay Vaidya (ORCID: https://orcid.org/0000-0002-2223-0494)
- David J. Carey (ORCID: https://orcid.org/0000-0001-6404-1950)
- Martina Owens (ORCID: https://orcid.org/0000-0002-2081-0188)
- Kashyap Patel (ORCID: https://orcid.org/0000-0002-9240-8104)
- Ankit M Arni (ORCID: https://orcid.org/0009-0005-0365-9235)
- C West
Institutions
- Institute of Cancer Research (GB)
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Genomic Health (United States) (US)
- Geisinger Health System (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.17937
- Citations
- 6
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.77