Upadacitinib for the Treatment of Upper Gastrointestinal Crohn's Disease

Data on the use of antitumor necrosis factor therapy have shown some positive outcomes in case reports or small observational studies such as the data showing the benefit of adalimumab in this rare presentation of Crohn's disease. To our knowledge, there is no published data on the use of upadacitinib in the treatment of upper gastrointestinal Crohn's disease. We present a case report of a young patient with severe oral and esophageal Crohn's disease that was successfully treated with upadacitinib.